Lag Times between Lymphoproliferative Disorder and Clinical Diagnosis of Chronic Lymphocytic Leukemia: A Prospective Analysis Using Plasma Soluble CD23
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چکیده
منابع مشابه
Lag times between lymphoproliferative disorder and clinical diagnosis of chronic lymphocytic leukemia: a prospective analysis using plasma soluble CD23.
BACKGROUND Chronic lymphocytic leukemia (CLL) is a chronic disease that often progresses slowly from a precursor stage, monoclonal B-cell lymphocytosis (MBL), and that can remain undiagnosed for a long time. METHODS Within the European Prospective Investigation into Cancer cohort, we measured prediagnostic plasma sCD23 for 179 individuals who eventually were diagnosed with CLL and an equal nu...
متن کاملChronic lymphocytic leukemia, biology, new diagnosis and treatment: review article
Chronic lymphocytic leukemia (CLL) is a malignancy of B CD5+cells and is the most common type of leukemia in adults. The disease is more common in men over 50 years in western countries. CLL is associated with defective apoptosis in B cells. CLL was traditionally regarded as a disease that occurs before naïve B cells meet the antigen in the lymph nodes. Laboratory diagnosis requires white blood...
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E, Biondi F, Lo Coco F, Grignani F, Pelicci PG: Acute promyelocytic REFERENCES leukemia: From genetics to treatment. Blood 83:10, 1994 1. Wada H, Mizutani S, Nishimura J, Usuki Y, Kohsaki M, Komai 5. Nucifora G, Rowley JD: The AML1 and ETO genes in acute M, Kaneko H, Sakamoto S, Delia D, Kanamaru A, Kakishita E: myeloid leukemia with a t(8;21). Leuk Lymphoma 14:353, 1994 Establishment and molec...
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Prognosis of B-cell chronic lymphocytic leukemia (CLL) is based on clinical staging whose limitation is the failure to assess whether the disease will progress or remain stable in early stage (Binet A, or Rai 0, I, II) patients. We previously reported that soluble CD23 (sCD23), a protein derived from the B-cell membrane CD23 Ag, is selectively elevated in the serum of CLL patients. This prospec...
متن کاملClinical Significance of Plasma Levels of Soluble CD40 in Patients with Chronic Lymphocytic Leukemia
CD40 ligation provides signals central to chronic lymphocytic leukemia (CLL) cell survival and proliferation. The release of soluble CD40 (sCD40) may impact on both these signals and CD40 targeted therapies. In this study we investigated the prognostic significance of plasma sCD40 in untreated CLL patients (n = 34). We report that 56% had levels higher than those of normal donors and that eleva...
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ژورنال
عنوان ژورنال: Cancer Epidemiology Biomarkers & Prevention
سال: 2014
ISSN: 1055-9965,1538-7755
DOI: 10.1158/1055-9965.epi-14-1107